The increasing convergence of zoonotic disease emergence, antimicrobial resistance, food system vulnerabilities, and environmental degradation has intensified the imperative to operationalize the One Health (OH) approach as a coordinated, cross-sectoral response. Recent global commitments, including those articulated at the OH Summit (Lyon, 2026), signal a decisive shift from conceptual alignment toward implementation, prevention, and systems integration, underpinned by a strengthened science-policy-society interface, data convergence, and sustained financing mechanisms. In this context, the Capacitating One Health in Eastern and Southern Africa (COHESA) presents a validated regional model for translating OH principles into practice. The programme is anchored in an academic institutions-driven architecture that enables localized institutional coordination, cross-sectoral integration, and operationalization of One Health, while fostering a regional network of actors spanning research, policy, and implementation domains. This webinar, scheduled for 7 May 2026 (11:00 – 12:30, UTC+3 EAT), will convene the COHESA network alongside global OH stakeholders to position COHESA as a scalable, systems-based solution aligned with emerging global health security priorities. Anchored in the outcomes of the OH Summit, the session will emphasize evidence-based pathways from research to policy and practice, while highlighting opportunities for partnership, investment alignment, and programmatic scale-up. Through a structured synthesis of COHESA impacts, country-level experiences, and beneficiary testimonies, the webinar will demonstrate how the programme contributes to the institutionalization and operationalization of OH, capacity development, and community-level delivery, thereby bridging global commitments and local action. In doing so, the webinar will also advance the proposition that OH should be more explicitly integrated into broader development, investment, and policy dialogues in high-level regional convenings.