As populations grow, climate change intensifies and people move closer to wildlife and livestock, the risks of conflict, resource competition and zoonotic diseases are rising. In this episode, we explore the One Health approach with Dr. Raymond Hamonga, Zambia’s National One Health Coordinator, who shares lessons from Zambia’s response to anthrax, the power of multi-sectoral coordination, and why scientists must communicate clearly with communities, policymakers and the public to protect human, animal and environmental health.